Thursday, 2 February 2012

Mast cell stabilizers used in the treatment of asthma


Mast cell stabilizers are also becoming popular in the treatment of asthma. They act by inhibiting the release of mediators such as histamine from the mast cells and hence prevent the asthma attack. This over secretion of mediators from the mast cells is one of the chief reasons of asthma.

Individual mast cell stabilisers for asthma

1. Sodium Cromoglycate (Cromolyn Sodium) - Sodium cromoglycate is the first drug used in this class. Cromolyn sodium is synthetic derivative of chromone. It acts by preventing the release of asthmatic mediators like histamine, leukotrienes, interleukins, PAF etc. from mast cells.

Sodium cromoglycate does not affect the antigen-antibody reaction and hence it has no effect if used at the time of asthmatic attack. Sodium cromoglycate is effective in the prevention of bronchospasm caused by any reason. However, long term use of Sodium cromoglycate decreases the response of inflammatory cells.

Sodium cromoglycate is orally ineffective drug and so most preferably it is administered as aerosol preparation. Sodium cromoglycate is used in the treatment of bronchial asthma, allergic rhinitis and allergic conjunctivitis.

The main adverse effects of Sodium cromoglycate include bronchospasm, throat irritation and cough can occur in some patients. Rare side effects are nasal congestion, headache, dizziness, arthralgia, rashes and dysuria.

2. Nedocromil Sodium – Nedocromil Sodium is another chromone derivative which is almost similar in action to the cromoglycate. The only difference with the Sodium cromoglycate is that it is more potent than the same and hence requires lesser dose.

3. Ketotifen – This is the only orally active mast cell stabilizer. Primarily this drug is antihistaminic (H1) and slightly cromoglycate type activity. Ketotifen chemically is non chromone derivative and primarily used for the prophylaxis of asthma.
The main side effects of ketotifen include sedation, dry mouth, dizziness, nausea, weight gain etc.

Note- This article is written for the purpose of providing you the basic knowledge of the topic and should not be taken as for prescription.

Other suggested readings for the treatment of asthma-
1. Treatment of asthma by sympathomimetic drugs.
2.Herbal drugs used for the treatment asthma

5 comments:

  1. Thanks for sharing this extremely informative article on asthma treatment. I recently read about Asthma treatment, preventive measures to control and medication for Asthma on breathefree.com. I found it extremely helpful.

    ReplyDelete
  2. Online ups system - Find here online ups system manufacturers, suppliers in delhi, India. We provide online ups system manufacturers in delhi, India. VIEW MORE :-Online UPS System in India

    ReplyDelete
  3. Thank you very much for the information provided! I was looking for this data for a long time, but I was not able to find the trusted source..
    Racz Epidural Neurolysis
    Radiofrequency Lesioning
    Spinal Cord Stimulation
    Selective Nerve Root Block
    Sympathetic Nerve Block For Pain
    Vertebroplasty

    ReplyDelete
  4. There is a safe & effective Natural Herbal Medicine. For Total Cure Call    +2349010754824,  or email him   drrealakhigbe@gmail.com       For an Appointment with (Dr.) AKHIGBE contact him. Treatment with Natural Herbal Cure. For:Dengue Fever, Malaria. Painful or Irregular Menstruation. HIV/Aids. Diabetics. Vaginal Infections. Vaginal Discharge. Itching Of the Private Part. Breast Infection. Discharge from Breast. Breast Pain & Itching. Lower Abdominal Pain. No Periods or Periods Suddenly Stop. Women Sexual Problems. High Blood Pressure Chronic Disease. Pain during Sex inside the Pelvis. Pain during Urination. Pelvic Inflammatory Disease, (PID). Dripping Of Sperm from the Vagina As Well As for Low sperm count. Parkinson disease. Obesity, Lupus.  Cancer.  Tuberculosis.  Zero sperm count. Bacteria, Impotence Fertility,Toxoplasmosis, Diarrhea.Herpatitis A&B, Rabies. Asthma.  Quick Ejaculation. Gallstone, Cystic Fibrosis, Schizophrenia, Cirrhosis,  Premature Ejaculation. Herpes. Joint Pain. Stroke. Cornelia Disease, Weak Erection. Ovarian problem,  Erysipelas, Thyroid, Discharge from Penis. Bronchial Problem,  HPV.  Hepatitis A and B. STD. Staphylococcus + Gonorrhea + Syphilis. Heart Disease.  Pile-Hemorrhoid.rheumatism,  Impotence, thyroid, Autism, Sepsis Bacteria,  Penis enlargement, Prostate Problem,  Waist & Back Pain.  Male Infertility and Female Infertility. Etc. Take Action Now. contact him & Order for your Natural Herbal Medicine:  +2349010754824  and email him    drrealakhigbe@gmail.com    Note For an Appointment with (Dr.) AKHIGBE.I suffered in Cancer for a year and three months dieing in pain and full of heart break. One day I was searching through the internet and I came across a testimony herpes cure by doctor Akhigbe. So I contact him to try my luck, we talk and he send me the medicine through courier service and with instructions on how to be drinking it.To my greatest surprise drinking the herbal medicine within three weeks I got the changes and I was cure totally. I don't really know how it happen but there is power in Dr Akhigbe herbal medicine. He is a good herbalist doctor.

    ReplyDelete